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Article

Pharmacogenomics of chemotherapy induced peripheral neuropathy using an electronic health record-derived definition: a genome-wide association study.

Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer - 8 Apr 2025

Jones Michael K, Nicklawsky Andrew, Shortt Jonathan, Pattee Jack, Kennerley Victoria, Eule Corbin J, Candelario Nellowe, O'Donnell Peter H, Flaig Thomas W

Abstract excerpt

PURPOSE: Prior studies evaluating the genetic predisposition to chemotherapy induced peripheral neuropathy (CIPN) have been limited by small populations due to difficulty with real-world data extraction. This genome-wide association study (GWAS) evaluates the genetic differences between patients who developed CIPN against those unaffected, using an electronic health record (EHR) definition of CIPN. METHODS: This...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 40198382
DOI: 10.1007/s00520-025-09392-y
PMCID: PMC13502521

Genes

CLDN14
RCOR1
TMC2
TRIM5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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