Article
Senescent Vascular Smooth Muscle Cells Drive Inflammation Through an Interleukin-1α-Dependent Senescence-Associated Secretory Phenotype.
Arteriosclerosis, thrombosis, and vascular biology - 1 Sept 2015
Gardner Sarah E, Humphry Melanie, Bennett Martin R, Clarke Murray C H
Abstract excerpt
OBJECTIVE: Vascular smooth muscle cells (VSMCs) that become senescent are both present within atherosclerotic plaques and thought to be important to the disease process. However, senescent VSMCs are generally considered to only contribute through inaction, with failure to proliferate resulting in VSMC- and collagen-poor unstable fibrous caps. Whether senescent VSMCs can actively contribute to atherogenic...
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