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Article

JAK inhibition alleviates the cellular senescence-associated secretory phenotype and frailty in old age

2 Nov 2015

Abstract excerpt

Chronic, low grade, sterile inflammation frequently accompanies aging and age-related diseases. Cellular senescence is associated with the production of proinflammatory chemokines, cytokines, and extracellular matrix (ECM) remodeling proteases, which comprise the senescence-associated secretory phenotype (SASP). We found a higher burden of senescent cells in adipose tissue with aging. Senescent human primary...

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PMID: 26578790
DOI: 10.1073/pnas.1515386112

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