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Article

Impairment of Macrophage Functions by the Senescence-Associated Secretory Phenotype of Vascular Smooth Muscle Cells-Brief Report.

Arteriosclerosis, thrombosis, and vascular biology - 1 May 2026

Tsitsipatis Dimitrios, Rodriguez Rivera Tatiana, Kaileh Mary, Okereke Ada N, Gupta Aditi, Singh Amit, Raph Sean M, Henry-Smith Charnae', Herman Allison B

Abstract excerpt

BACKGROUND: This study aimed to determine the effect of senescent vascular smooth muscle cells (VSMCs) on foam cell formation and macrophage phagocytic activity in atherosclerotic conditions. METHODS: We measured the capacity of senescent VSMCs for scavenging oxLDL (oxidized low-density lipoprotein), which was impaired in senescent cells compared with proliferating and quiescent cells. Next, we obtained human...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41924876
DOI: 10.1161/ATVBAHA.125.324299
PMCID: PMC13098668

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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