Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Senescence: An Overlooked VSMC Phenotype and Therapeutic Opportunity?

Arteriosclerosis, thrombosis, and vascular biology - 1 Jan 2026

Herman Allison B, Gresova Katarina, Maragkakis Manolis, Autieri Michael V

Abstract excerpt

Vascular smooth muscle cells (VSMCs) modulate their phenotype from a quiescent, contractile cell to a dedifferentiated, synthetic fibroproliferative cell in response to injury and cardiovascular risk factors. Senescence is a recognized phenotypically distinct cellular state characterized by cell cycle arrest and activation of the p16 and p53 damage response pathway and expression of the senescence-associated...

Topics

Join the communities discussing this publication.

Cardiovascular Diseases
Cell Plasticity
Cellular Senescence
Muscle, Smooth, Vascular
Myocytes, Smooth Muscle

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Signal Transduction

Source

Open in PubMed Open full text

Identifiers

PMID: 41230598
DOI: 10.1161/ATVBAHA.125.323131
PMCID: PMC12742571

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Senescence: An Overlooked VSMC Phenotype and Therapeutic Opportunity?PMID 41230598Read ↗

Integration of Vascular Smooth Muscle Cell Phenotypic Switching and Senescence.Semantic proximity Read ↗

Cellular Senescence and Vascular Disease: Novel Routes to Better Understanding and Therapy.Semantic proximity Read ↗

Pathophysiology of vascular calcification: Pivotal role of cellular senescence in vascular smooth muscle cells.Semantic proximity Read ↗

Vascular smooth muscle cell senescence in atherosclerosisSemantic proximity Read ↗

Premature cell senescence promotes vascular smooth muscle cell phenotypic modulation and resistance to re-differentiation.Semantic proximity Read ↗

Vascular senescence and aging: mechanisms, clinical implications, and therapeutic prospectsSemantic proximity Read ↗

Senescent Vascular Smooth Muscle Cells Drive Inflammation Through an Interleukin-1α-Dependent Senescence-Associated Secretory Phenotype.Semantic proximity Read ↗

The emerging role of cell senescence in atherosclerosisSemantic proximity Read ↗

Novel Contributors and Mechanisms of Cellular Senescence in Hypertension-Associated Premature Vascular AgingSemantic proximity Read ↗

Vascular smooth muscle cell senescence and age-related diseases: State of the artSemantic proximity Read ↗

Understanding the intricacies of cellular senescence in atherosclerosis: Mechanisms and therapeutic implications.Semantic proximity Read ↗

Replicative Senescence in Vascular Smooth Muscle Cells: PURPL and NEAT1 Long Non-Coding RNAs as New Senescence-Associated BiomarkersSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.