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Secretory products from regulatory macrophages modulate senescence in human endothelial cells: implications for cardiovascular aging and diseases.

BMC cardiovascular disorders - 31 Mar 2026

Delfs Katharina, Berndt Rouven, Hess Katharina, Eimer Christine, Fändrich Fred, Steinfath Markus, Zitta Karina, Albrecht Martin

Abstract excerpt

BACKGROUND: Cardiovascular diseases (CVDs) are the leading cause of mortality worldwide and primarily affect older individuals, making CVDs a central concern in age-related and geriatric medicine. Senescent endothelial cells contribute to a pro-inflammatory environment that exacerbates cardiovascular pathology. Therapies targeting senescent cells, hold promise for treating/preventing CVDs and anti-inflammatory...

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PMID: 41917842
DOI: 10.1186/s12872-026-05732-w
PMCID: PMC13063746

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