Article
BclI glucocorticoid receptor polymorphism in relation to cardiovascular variables: the Hoorn and CODAM studies.
European journal of endocrinology - 1 Oct 2015
van Moorsel Dirk, van Greevenbroek Marleen M J, Schaper Nicolaas C, Henry Ronald M A, Geelen Charlotte C, van Rossum Elisabeth F C, Nijpels Giel, 't Hart Leen M, Schalkwijk Casper G, van der Kallen Carla J H, Sauerwein Hans P, Dekker Jacqueline M, Stehouwer Coen D A, Havekes Bas
Abstract excerpt
OBJECTIVE: Excess glucocorticoids are known to cause hypertension and cardiovascular disease (CVD). The BclI glucocorticoid receptor (GR) polymorphism increases glucocorticoid sensitivity and is associated with adverse metabolic effects. Previous studies investigating cardiovascular implications have shown inconsistent results. Therefore, the aim of the present study was to investigate the association of the BclI...
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