Characterization of the BclI Polymorphism in the Glucocorticoid Receptor Gene

Abstract excerpt

Glucocorticoids (GCs) have a major antiproliferative effect, which has led to the use of their synthetic homologs for immunosuppression, treatment of inflammation, and induction of cytotoxicity (1)(2). GCs exert their effect by binding to an intracellular GC receptor (GR), forming a complex that translocates to the nucleus, where GCs then regulate the expression of target genes interacting with promoter...