Article
BclI Glucocorticoid Receptor Polymorphism in Relation to Arterial Stiffening and Cardiac Structure and Function: The Hoorn and CODAM Studies.
American journal of hypertension - 1 Mar 2017
van Moorsel Dirk, Henry Ronald M, Schaper Nicolaas C, van Greevenbroek Marleen M, van Rossum Elisabeth F, 't Hart Leen M, Schalkwijk Casper G, van der Kallen Carla J, Dekker Jacqueline M, Stehouwer Coen D, Havekes Bas
Abstract excerpt
BACKGROUND: Chronic glucocorticoid excess is associated with arterial stiffening and cardiac dysfunction. The BclI glucocorticoid receptor (GR) polymorphism increases GR sensitivity and is associated with a higher body mass index (BMI) and some proxies for cardiovascular disease (CVD). Whether BclI influences arterial stiffening and cardiac dysfunction is currently unknown. Therefore, the aim of the present study...
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