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Article

A common Shox2-Nkx2-5 antagonistic mechanism primes the pacemaker cell fate in the pulmonary vein myocardium and sinoatrial node.

Development (Cambridge, England) - 15 Jul 2015

Ye Wenduo, Wang Jun, Song Yingnan, Yu Diankun, Sun Cheng, Liu Chao, Chen Fading, Zhang Yanding, Wang Fen, Harvey Richard P, Schrader Laura, Martin James F, Chen YiPing

Abstract excerpt

In humans, atrial fibrillation is often triggered by ectopic pacemaking activity in the myocardium sleeves of the pulmonary vein (PV) and systemic venous return. The genetic programs that abnormally reinforce pacemaker properties at these sites and how this relates to normal sinoatrial node (SAN) development remain uncharacterized. It was noted previously that Nkx2-5, which is expressed in the PV myocardium and...

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Identifiers

PMID: 26138475
DOI: 10.1242/dev.120220
PMCID: PMC4510860

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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