Article
Generation of Shox2-Cre allele for tissue specific manipulation of genes in the developing heart, palate, and limb.
Genesis (New York, N.Y. : 2000) - 1 Jul 2013
Sun Cheng, Zhang Tao, Liu Chao, Gu Shuping, Chen YiPing
Abstract excerpt
Shox2 is expressed in several developing organs in a tissue specific manner in both mice and humans, including the heart, palate, limb, and nervous system. To better understand the spatial and temporal expression patterns of Shox2 and to systematically dissect the genetic cascade regulated by Shox2, we created Shox2-LacZ and Shox2-Cre knock-in mouse lines. We show that the Shox2-LacZ allele expresses...
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