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Article

Functional redundancy between human SHOX and mouse Shox2 genes in the regulation of sinoatrial node formation and pacemaking function.

The Journal of biological chemistry - 13 May 2011

Liu Hongbing, Chen Chao-Hui, Espinoza-Lewis Ramón A, Jiao Zhen, Sheu Ivana, Hu Xuefeng, Lin Minkui, Zhang Yanding, Chen YiPing

Abstract excerpt

The homeodomain transcription factor Shox2 plays a crucial regulatory role in the development of sinoatrial node (SAN) by repressing the expression of Nkx2.5, as demonstrated by failed differentiation of SAN in Shox2 null mice. The SHOX (short stature homeobox) gene family consists of two closely related members, SHOX and SHOX2 in humans, but a SHOX ortholog does not exist in the mouse genome. These two genes...

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Share to Arrhythmias, Cardiac
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Homeobox Protein Nkx-2.5

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Source

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Identifiers

PMID: 21454626
DOI: 10.1074/jbc.M111.234252
PMCID: PMC3089547

Genes

SHOX
SHOX2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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