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Article

Nkx2-5 and Sarcospan genetically interact in the development of the muscular ventricular septum of the heart.

Scientific reports - 13 Apr 2017

Panzer Adam A, Regmi Suk D, Cormier DePorres, Danzo Megan T, Chen Iuan-Bor D, Winston Julia B, Hutchinson Alayna K, Salm Diana, Schulkey Claire E, Cochran Rebecca S, Wilson David B, Jay Patrick Y

Abstract excerpt

The muscular ventricular septum separates the flow of oxygenated and de-oxygenated blood in air-breathing vertebrates. Defects within it, termed muscular ventricular septal defects (VSDs), are common, yet less is known about how they arise than rarer heart defects. Mutations of the cardiac transcription factor NKX2-5 cause cardiac malformations, including muscular VSDs. We describe here a genetic interaction...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28406175
DOI: 10.1038/srep46438
PMCID: PMC5390293

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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