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Article

Transcriptome analysis of mouse and human sinoatrial node cells reveals a conserved genetic program

1 Jan 2019

Abstract excerpt

The rate of contraction of the heart relies on proper development and function of the sinoatrial node, which consists of a small heterogeneous cell population, including Tbx3+ pacemaker cells. Here we isolated and characterized the Tbx3+ cells from Tbx3+/Venus knock-in mice. We studied electrophysiological parameters during development and found that Venus-labeled cells are genuine Tbx3+ pacemaker cells. We...

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PMID: 30936179
DOI: 10.1242/dev.173161

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