Article
The short stature homeobox 2 (Shox2)-bone morphogenetic protein (BMP) pathway regulates dorsal mesenchymal protrusion development and its temporary function as a pacemaker during cardiogenesis.
The Journal of biological chemistry - 23 Jan 2015
Sun Cheng, Yu Diankun, Ye Wenduo, Liu Chao, Gu Shuping, Sinsheimer Nathan R, Song Zhongchen, Li Xihai, Chen Chun, Song Yingnan, Wang Shusheng, Schrader Laura, Chen YiPing
Abstract excerpt
The atrioventricular (AV) junction plays a critical role in chamber septation and transmission of cardiac conduction pulses. It consists of structures that develop from embryonic dorsal mesenchymal protrusion (DMP) and the embryonic AV canal. Despite extensive studies on AV junction development, the genetic regulation of DMP development remains poorly understood. In this study we present evidence that Shox2 is...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.