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Article

Nkx2-5 Suppresses the Proliferation of Atrial Myocytes and Conduction System

22 Feb 2014

Abstract excerpt

RATIONALE: Tight control of cardiomyocyte proliferation is essential for the formation of four-chambered heart. Although human mutation of NKX2-5 is linked to septal defects and atrioventricular conduction abnormalities, early lethality and hemodynamic alteration in the mutant models have caused controversy as to whether Nkx2-5 regulates cardiomyocyte proliferation. OBJECTIVE: In this study, we circumvented these...

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Identifiers

PMID: 24563458
DOI: 10.1161/circresaha.114.303219

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Related research

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