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Flavivirus induces and antagonizes antiviral RNA interference in both mammals and mosquitoes

6 Feb 2020

Abstract excerpt

Mosquito-borne flaviviruses infect both mammals and mosquitoes. RNA interference (RNAi) has been demonstrated as an anti-flavivirus mechanism in mosquitoes; however, whether and how flaviviruses induce and antagonize RNAi-mediated antiviral immunity in mammals remains unknown. We show that the nonstructural protein NS2A of dengue virus-2 (DENV2) act as a viral suppressor of RNAi (VSR). When NS2A-mediated RNAi...

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PMID: 32076641
DOI: 10.1126/sciadv.aax7989

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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