Single Nucleotide Polymorphism (rs4932178) in the P1 Promoter of FURIN Is Not Prognostic to Colon Cancer.

doi:10.1155/2015/321276

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Article

Single Nucleotide Polymorphism (rs4932178) in the P1 Promoter of FURIN Is Not Prognostic to Colon Cancer.

BioMed research international - 1 Jan 2015

Declercq Jeroen, Jacobs Bart, Biesmans Bart, Roth Arnaud, Klingbiel Dirk, Tejpar Sabine, Creemers John W

Abstract excerpt

High expression of the proprotein processing enzyme FURIN has been associated with tumor progression and metastasis. A SNP (rs4932178) in the promoter of FURIN has been reported to affect expression in liver, with the T allele resulting in higher expression than the C allele. In this study we have investigated the association of this SNP with prognostic and biological subgroups of colorectal cancer (CRC). In a...

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PMID: 26137475
DOI: 10.1155/2015/321276
PMCID: PMC4475562

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FURIN

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