Article
Single nucleotide polymorphism in the hypoxia-inducible factor-1alpha gene in colorectal carcinoma.
Oncology reports - 1 Nov 2004
Kuwai Toshio, Kitadai Yasuhiko, Tanaka Shinji, Kuroda Tsuyoshi, Ochiumi Takehiko, Matsumura Shunji, Oue Naohide, Yasui Wataru, Kaneyasu Mika, Tanimoto Keiji, Nishiyama Masahiko, Chayama Kazuaki
Abstract excerpt
Colorectal carcinoma is one of the most common malignancies in the world, and its incidence has increased in recent years. We have reported that expression of hypoxia-inducible factor (HIF)-1alpha correlates with expression of vascular endothelial growth factor (VEGF), tumor stage, lymphatic invasion, venous invasion, and liver metastasis. It has also been reported that a single nucleotide polymorphism (SNP) in...
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