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Article

Germline variation in colorectal risk Loci does not influence treatment effect or survival in metastatic colorectal cancer.

PloS one - 1 Jan 2014

Sanoff Hanna K, Renfro Lindsay A, Poonnen Pradeep, Ambadwar Pratibha, Sargent Daniel J, Goldberg Richard M, McLeod Howard

Abstract excerpt

BACKGROUND: Colorectal cancer (CRC) risk is partly conferred by common, low-penetrance single nucleotide polymorphisms (SNPs). We hypothesized that these SNPs are associated with outcomes in metastatic CRC. METHODS: Six candidate SNPs from 8q24, 10p14, 15q13, 18q21 were investigated for their association with response rate (RR), time to progression (TTP) and overall survival (OS) among 524 patients treated on a...

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Identifiers

PMID: 24727911
DOI: 10.1371/journal.pone.0094727
PMCID: PMC3984266

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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