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Article

CASP8 variants D302H and -652 6N ins/del do not influence the risk of colorectal cancer in the United Kingdom population.

British journal of cancer - 22 Apr 2008

Pittman A M, Broderick P, Sullivan K, Fielding S, Webb E, Penegar S, Tomlinson I, Houlston R S

Abstract excerpt

Polymorphisms in CASP8 at 2q33.1 have been associated with the risk of developing cancer, specifically, the D302H variant (rs1045485) with breast cancer in the European population and the -652 6N ins/del promoter variant (rs3834129) with multiple tumours including colorectal cancer (CRC) in the Chinese population. We evaluated the relationship between -652 6N ins/del and D302H variants and risk of developing CRC...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 18362937
DOI: 10.1038/sj.bjc.6604314
PMCID: PMC2361709

Genes

CASP8

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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CASP8 variants D302H and -652 6N ins/del do not influence the risk of colorectal cancer in the United Kingdom population.PMID 18362937Read ↗

Association between CASP8 -652 6N del polymorphism (rs3834129) and colorectal cancer risk: results from a multi-centric study.Semantic proximity Read ↗

A systematic analysis of the association studies between CASP8 D302H polymorphisms and breast cancer risk.Semantic proximity Read ↗

CASP8 -652 6N del polymorphism contributes to colorectal cancer susceptibility: evidence from a meta-analysis.Semantic proximity Read ↗

CASP8 polymorphisms contribute to cancer susceptibility: evidence from a meta-analysis of 23 publications with 55 individual studies.Semantic proximity Read ↗

The relationship of CASP 8 polymorphism and cancer susceptibility: a meta-analysis.Semantic proximity Read ↗

Colorectal cancer risk is not associated with increased levels of homozygosity in a population from the United Kingdom.Semantic proximity Read ↗

CASP8 D302H and meningioma risk: an analysis of five case-control series.Semantic proximity Read ↗

Genetic polymorphisms of the CASP8 gene promoter may not be associated with colorectal cancer in Han Chinese from southwest China.Semantic proximity Read ↗

CASP8 -652 6N del polymorphism and cancer risk: a meta-analysis of 30 case-control studies in 50,112 subjects.Semantic proximity Read ↗

The APC gene I1307K variant is rare in Norwegian patients with familial and sporadic colorectal or breast cancer.Semantic proximity Read ↗

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