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Article

Association of hypoxia-inducible factor 1-alpha gene polymorphisms and colorectal cancer prognosis.

Anticancer research - 1 Jun 2010

Szkandera Joanna, Knechtel Gudrun, Stotz Michael, Hofmann Günter, Langsenlehner Uwe, Krippl Peter, Langsenlehner Tanja, Dehchamani Dadbeh, Samonigg Hellmut, Renner Wilfried, Gerger Armin

Abstract excerpt

BACKGROUND: Hypoxia inducible factor-1 (HIF-1) is the key regulator of cellular responses to hypoxia and plays a central role in tumour growth. Recently, two single nucleotide polymorphisms (SNPs) in the HIF-1 alpha gene, C1772T and G1790A, were shown to cause significantly higher transcriptional activity than did the wild-type. This study aimed to investigate the effect of these SNPs on the prognosis of...

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PMID: 20651398

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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