Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Endoplasmic reticulum aminopeptidase-1 alleles associated with increased risk of ankylosing spondylitis reduce HLA-B27 mediated presentation of multiple antigens.

Autoimmunity - 1 Dec 2013

Seregin Sergey S, Rastall David P W, Evnouchidou Irini, Aylsworth Charles F, Quiroga Dionisia, Kamal Ram P, Godbehere-Roosa Sarah, Blum Christopher F, York Ian A, Stratikos Efstratios, Amalfitano Andrea

Abstract excerpt

Ankylosing spondylitis (AS) is a chronic systemic arthritic disease that leads to significant disability and loss of quality of life in the ∼0.5% of the worldwide human population it affects. There is currently no cure for AS and mechanisms underlying its pathogenesis remain unclear. AS is highly genetic, with over 70% of the genetic risk being associated with the presence of HLA-B27 and endoplasmic reticulum...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aminopeptidases
Share to Antigen Presentation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epitopes

Share to HLA-B27 Antigen

Share to Minor Histocompatibility Antigens

Share to Peptides

Share to Reproducibility of Results

Share to Spondylitis, Ankylosing

Source

Open in PubMed Open full text

Identifiers

PMID: 24028501
DOI: 10.3109/08916934.2013.819855
PMCID: PMC4104477

Genes

ERAP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Endoplasmic reticulum aminopeptidase-1 alleles associated with increased risk of ankylosing spondylitis reduce HLA-B27 mediated presentation of multiple antigens.PMID 24028501Read ↗

Functionally distinct ERAP1 allotype combinations distinguish individuals with Ankylosing Spondylitis.Semantic proximity Read ↗

Functional interaction of the ankylosing spondylitis-associated endoplasmic reticulum aminopeptidase 1 polymorphism and HLA-B27 in vivo.Semantic proximity Read ↗

ERAP1 in the pathogenesis of ankylosing spondylitis.Semantic proximity Read ↗

ERAP1 and ankylosing spondylitis.Semantic proximity Read ↗

ERAP1 in ankylosing spondylitis: genetics, biology and pathogenetic role.Semantic proximity Read ↗

ERAP1 structure, function and pathogenetic role in ankylosing spondylitis and other MHC-associated diseases.Semantic proximity Read ↗

Endoplasmic reticulum aminopeptidases in the pathogenesis of ankylosing spondylitis: Fig. 1Semantic proximity Read ↗

Critical role of endoplasmic reticulum aminopeptidase 1 in determining the length and sequence of peptides bound and presented by HLA-B27.Semantic proximity Read ↗

Biology of HLA class I associated inflammatory diseases.Semantic proximity Read ↗

Endoplasmic reticulum aminopeptidase 1 (ERAP1) exhibits functionally significant interaction with HLA-B27 and relates to subtype specificity in ankylosing spondylitis.Semantic proximity Read ↗

Separate effects of the ankylosing spondylitis associated ERAP1 and ERAP2 aminopeptidases determine the influence of their combined phenotype on the HLA-B*27 peptidome.Semantic proximity Read ↗

Peptide handling by HLA-B27 subtypes influences their biological behavior, association with ankylosing spondylitis and susceptibility to endoplasmic reticulum aminopeptidase 1 (ERAP1).Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.