Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

CpG-related SNPs in the MS4A region have a dose-dependent effect on risk of late-onset Alzheimer disease.

Aging cell - 1 Aug 2019

Ma Yiyi, Jun Gyungah R, Chung Jaeyoon, Zhang Xiaoling, Kunkle Brian W, Naj Adam C, White Charles C, Bennett David A, De Jager Philip L, Mayeux Richard, Haines Jonathan L, Pericak-Vance Margaret A, Schellenberg Gerard D, Farrer Lindsay A, Lunetta Kathryn L

Abstract excerpt

CpG-related single nucleotide polymorphisms (CGS) have the potential to perturb DNA methylation; however, their effects on Alzheimer disease (AD) risk have not been evaluated systematically. We conducted a genome-wide association study using a sliding-window approach to measure the combined effects of CGSes on AD risk in a discovery sample of 24 European ancestry cohorts (12,181 cases, 12,601 controls) from the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alzheimer Disease
Share to Brain

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cohort Studies

Share to CpG Islands

Share to Dinucleoside Phosphates

Share to DNA Methylation

Share to Quantitative Trait Loci

Source

Open in PubMed Open full text

Identifiers

PMID: 31144443
DOI: 10.1111/acel.12964
PMCID: PMC6612647

Genes

MS4A4A
APOE
BIN1
MS4A6A
PICALM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

CpG-related SNPs in the MS4A region have a dose-dependent effect on risk of late-onset Alzheimer disease.PMID 31144443Read ↗

Multi-omics Characterization of Epigenetic and Genetic Risk of Alzheimer Disease in Autopsied Brains from two Ethnic GroupsSemantic proximity Read ↗

Whole genome methylation sequencing in blood identifies extensive differential DNA methylation in late‐onset dementia due to Alzheimer's diseaseSemantic proximity Read ↗

Integrated DNA methylation and gene expression profiling across multiple brain regions implicate novel genes in Alzheimer’s diseaseSemantic proximity Read ↗

Epigenetic and genetic risk of Alzheimer disease from autopsied brains in two ethnic groups.Semantic proximity Read ↗

Alzheimer's loci: epigenetic associations and interaction with genetic factorsSemantic proximity Read ↗

From aging to Alzheimer’s disease: concordant brain DNA methylation changes in late lifeSemantic proximity Read ↗

Methylation-wide association analysis reveals AIM2, DGUOK, GNAI3, and ST14 genes as potential contributors to the Alzheimer’s disease pathogenesisSemantic proximity Read ↗

The Aging Epigenome: Integrative Analyses Reveal Functional Overlap with Alzheimer’s DiseaseSemantic proximity Read ↗

<i>APOE</i>Genotype-specific Methylation Patterns are Linked to Alzheimer Disease Pathology and Estrogen ResponseSemantic proximity Read ↗

Epigenome-wide association study of Alzheimer’s disease replicates 22 differentially methylated positions and 30 differentially methylated regionsSemantic proximity Read ↗

Whole genome methylation sequencing in blood from persons with mild cognitive impairment and dementia due to Alzheimer’s disease identifies cognitive statusSemantic proximity Read ↗

Genome-wide QTL mapping across three tissues highlights several Alzheimer’s and Parkinson’s disease loci potentially acting via DNA methylationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.