Article
Harnessing peripheral DNA methylation differences in the Alzheimer's Disease Neuroimaging Initiative (ADNI) to reveal novel biomarkers of disease.
Clinical epigenetics - 15 Jun 2020
Vasanthakumar Aparna, Davis Justin W, Idler Kenneth, Waring Jeffrey F, Asque Elizabeth, Riley-Gillis Bridget, Grosskurth Shaun, Srivastava Gyan, Kim Sungeun, Nho Kwangsik, Nudelman Kelly N H, Faber Kelley, Sun Yu, Foroud Tatiana M, Estrada Karol, Apostolova Liana G, Li Qingqin S, Saykin Andrew J
Abstract excerpt
BACKGROUND: Alzheimer's disease (AD) is a chronic progressive neurodegenerative disease impacting an estimated 44 million adults worldwide. The causal pathology of AD (accumulation of amyloid-beta and tau), precedes hallmark symptoms of dementia by more than a decade, necessitating development of early diagnostic markers of disease onset, particularly for new drugs that aim to modify disease processes. To...
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