Article
miR-155 Controls Lymphoproliferation in LAT Mutant Mice by Restraining T-Cell Apoptosis via SHIP-1/mTOR and PAK1/FOXO3/BIM Pathways.
PloS one - 1 Jan 2015
Rouquette-Jazdanian Alexandre K, Kortum Robert L, Li Wenmei, Merrill Robert K, Nguyen Phan H, Samelson Lawrence E, Sommers Connie L
Abstract excerpt
Linker for Activation of T cells (LAT) is an adapter protein that is essential for T cell function. Knock-in mice with a LAT mutation impairing calcium flux develop a fatal CD4+ lymphoproliferative disease. miR-155 is a microRNA that is correlated with hyperproliferation in a number of cancers including lymphomas and leukemias and is overexpressed in mutant LAT T cells. To test whether miR-155 was merely...
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