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Article

p21-activated kinase 1 phosphorylates the death agonist bad and protects cells from apoptosis.

Molecular and cellular biology - 1 Jan 2000

Schürmann A, Mooney A F, Sanders L C, Sells M A, Wang H G, Reed J C, Bokoch G M

Abstract excerpt

Bad is a critical regulatory component of the intrinsic cell death machinery that exerts its death-promoting effect upon heterodimerization with the antiapoptotic proteins Bcl-2 and Bcl-x(L). Growth factors promote cell survival through phosphorylation of Bad, resulting in its dissociation from Bcl-2 and Bcl-x(L) and its association with 14-3-3tau. Survival of interleukin 3 (IL-3)-dependent FL5.12 lymphoid...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 10611223
DOI: 10.1128/MCB.20.2.453-461.2000
PMCID: PMC85099

Genes

PAK1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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