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Article

Foxo1 Serine 209 Is a Critical Regulatory Site of CD8 T Cell Differentiation and Survival.

Journal of immunology (Baltimore, Md. : 1950) - 1 Jan 2021

Hills Leonard Benjamin, Abdullah Leena, Lust Hannah E, Degefu Hanna, Huang Yina H

Abstract excerpt

Foxo1 is an essential transcription factor required for the survival and differentiation of memory CD8 T cells, yet it is unclear whether these Foxo1-dependent functions are inherently coupled. To address this question, we examined the effects of different Foxo1 posttranslational modifications. Phosphorylation of Foxo1 by Akt kinases at three distinct residues is well characterized to inhibit Foxo1...

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Identifiers

PMID: 33229443
DOI: 10.4049/jimmunol.2000216
PMCID: PMC7855204

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