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Article

Allosteric modulation of metabotropic glutamate receptors by chloride ions.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Oct 2015

Tora Amélie S, Rovira Xavier, Dione Ibrahima, Bertrand Hugues-Olivier, Brabet Isabelle, De Koninck Yves, Doyon Nicolas, Pin Jean-Philippe, Acher Francine, Goudet Cyril

Abstract excerpt

Metabotropic glutamate receptors (mGluRs) play key roles in the modulation of many synapses. Chloride (Cl(-)) is known to directly bind and regulate the function of different actors of neuronal activity, and several studies have pointed to the possible modulation of mGluRs by Cl(-). Herein, we demonstrate that Cl(-) behaves as a positive allosteric modulator of mGluRs. For example, whereas glutamate potency was...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 26116702
DOI: 10.1096/fj.14-269746

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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