Article
Mechanisms of anion conduction by coupled glutamate transporters.
Cell - 29 Jan 2015
Machtens Jan-Philipp, Kortzak Daniel, Lansche Christine, Leinenweber Ariane, Kilian Petra, Begemann Birgit, Zachariae Ulrich, Ewers David, de Groot Bert L, Briones Rodolfo, Fahlke Christoph
Abstract excerpt
Excitatory amino acid transporters (EAATs) are essential for terminating glutamatergic synaptic transmission. They are not only coupled glutamate/Na(+)/H(+)/K(+) transporters but also function as anion-selective channels. EAAT anion channels regulate neuronal excitability, and gain-of-function mutations in these proteins result in ataxia and epilepsy. We have combined molecular dynamics simulations with...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.