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Article

Mechanism of Cl- selection by a glutamate-gated chloride (GluCl) receptor revealed through mutations in the selectivity filter.

The Journal of biological chemistry - 26 May 2006

Sunesen Morten, de Carvalho Lia Prado, Dufresne Virginie, Grailhe Regis, Savatier-Duclert Nathalie, Gibor Gilad, Peretz Asher, Attali Bernard, Changeux Jean-Pierre, Paas Yoav

Abstract excerpt

To learn about the mechanism of ion charge selectivity by invertebrate glutamate-gated chloride (GluCl) channels, we swapped segments between the GluClbeta receptor of Caenorhabditis elegans and the vertebrate cationic alpha7-acetylcholine receptor and monitored anionic/cationic permeability ratios. Complete conversion of the ion charge selectivity in a set of receptor microchimeras indicates that the selectivity...

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PMID: 16527818
DOI: 10.1074/jbc.M511657200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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