Article
Chloride ions stabilize the glutamate-induced active state of the metabotropic glutamate receptor 3.
Neuropharmacology - 15 Sept 2018
Tora Amélie S, Rovira Xavier, Cao Anne-Marinette, Cabayé Alexandre, Olofsson Linnéa, Malhaire Fanny, Scholler Pauline, Baik Hayeon, Van Eeckhaut Ann, Smolders Ilse, Rondard Philippe, Margeat Emmanuel, Acher Francine, Pin Jean-Philippe, Goudet Cyril
Abstract excerpt
Due to the essential roles of glutamate, detection and response to a large range of extracellular concentrations of this excitatory amino acid are necessary for the fine-tuning of brain functions. Metabotropic glutamate receptors (mGluRs) are implicated in shaping the activity of many synapses in the central nervous system. Among the eight mGluR subtypes, there is increasing interest in studying the mGlu3...
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