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Article

Phosphoregulation of the intracellular termini of K+-Cl- cotransporter 2 (KCC2) enables flexible control of its activity.

The Journal of biological chemistry - 2 Nov 2018

Cordshagen Antje, Busch Wiebke, Winklhofer Michael, Nothwang Hans Gerd, Hartmann Anna-Maria

Abstract excerpt

The pivotal role of K+-Cl- cotransporter 2 (KCC2) in inhibitory neurotransmission and severe human diseases fosters interest in understanding posttranslational regulatory mechanisms such as (de)phosphorylation. Here, the regulatory role of the five bona fide phosphosites Ser31, Thr34, Ser932, Thr999, and Thr1008 was investigated by the use of alanine and aspartate mutants. Tl+-based flux analyses in HEK-293 cells...

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Identifiers

PMID: 30201606
DOI: 10.1074/jbc.RA118.004349
PMCID: PMC6222103

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