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Article

Determinants of endogenous ligand specificity divergence among metabotropic glutamate receptors.

The Journal of biological chemistry - 30 Jan 2015

Kang Hye Jin, Wilkins Angela D, Lichtarge Olivier, Wensel Theodore G

Abstract excerpt

To determine the structural origins of diverse ligand response specificities among metabotropic glutamate receptors (mGluRs), we combined computational approaches with mutagenesis and ligand response assays to identify specificity-determining residues in the group I receptor, mGluR1, and the group III receptors, mGluR4 and mGluR7. Among these, mGluR1 responds to L-glutamate effectively, whereas it binds weakly to...

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Identifiers

PMID: 25519912
DOI: 10.1074/jbc.M114.622233
PMCID: PMC4317032

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