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The mitochondrial DNA 4,977-bp deletion and its implication in copy number alteration in colorectal cancer

13 Jan 2011

Abstract excerpt

BACKGROUND: qualitative and quantitative changes in human mitochondrial DNA (mtDNA) have been implicated in various cancer types. A 4,977 bp deletion in the major arch of the mitochondrial genome is one of the most common mutations associated with a variety of human diseases and aging. METHODS: we conducted a comprehensive study on clinical features and mtDNA of 104 colorectal cancer patients in the Wenzhou area...

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PMID: 21232124
DOI: 10.1186/1471-2350-12-8

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