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Article

Disruption of thioredoxin metabolism enhances the toxicity of transforming growth factor β-activated kinase 1 (TAK1) inhibition in KRAS-mutated colon cancer cells.

Redox biology - 1 Aug 2015

Hrabe Jennifer E, O'Leary Brianne R, Fath Melissa A, Rodman Samuel N, Button Anna M, Domann Frederick E, Spitz Douglas R, Mezhir James J

Abstract excerpt

Transforming growth factor β-activated kinase 1 (TAK1) is critical for survival of many KRAS mutated colorectal cancer cells, and TAK1 inhibition with 5Z-7-oxozeaenol has been associated with oxidative stress leading to tumor cell killing. When SW 620 and HCT 116 human colon cancer cells were treated with 5µM 5Z-7-oxozeaenol, cell viability, growth, and clonogenic survival were significantly decreased. Consistent...

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Source

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Identifiers

PMID: 26114584
DOI: 10.1016/j.redox.2015.06.004
PMCID: PMC4491644

Genes

KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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