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Synergistic Dual Targeting of Thioredoxin and Glutathione Systems Irrespective of p53 in Glioblastoma Stem Cells<strong> </strong>

2024-09-10

Abstract excerpt

Glioblastoma (GBM) is an incurable primary brain cancer characterized by increased reactive oxygen species (ROS) production. The redox-sensitive tumor suppressor gene TP53, wildtype (wt) for 70% of patients, regulates redox homeostasis. Glioblastoma stem cells (GSCs) increase thioredoxin (Trx) and glutathione (GSH) antioxidant systems as survival redox-adaptive mechanisms to maintain ROS below the cytotoxic thresh...

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Literature Corpus work
1de972f9-3ca7-59bd-b883-9ce7518a96b8
DOI
10.20944/preprints202409.0790.v1
Open publication

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Synergistic Dual Targeting of Thioredoxin and Glutathione Systems Irrespective of p53 in Glioblastoma Stem Cells<strong> </strong>DOI 10.20944/preprints202409.0790.v1
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