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The dicarbonyl electrophile scavenger 2-hydroxybenzylamine (2-HOBA) prevents colorectal carcinogenesis and reduces tumor growth

2023-01-31

Abstract excerpt

<h4>Background: </h4> and Purpose: Colorectal cancer (CRC) is a major health problem worldwide. Dicarbonyl electrophiles, such as iso-levuglandins (isoLGs), are generated from lipid peroxidation and form covalent adducts with amine-containing macromolecules. We have shown high levels of adducts of isoLGs in colonic epithelial cells from patients with CRC. We thus investigated the role of these reactive aldehydes o...

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Literature Corpus work
6b85514d-7135-5fbe-a05c-6333bc968bd0
DOI
10.22541/au.167515663.34499902/v1
Open publication

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The dicarbonyl electrophile scavenger 2-hydroxybenzylamine (2-HOBA) prevents colorectal carcinogenesis and reduces tumor growthDOI 10.22541/au.167515663.34499902/v1
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