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Article

HDAC inhibitor, valproic acid, induces p53-dependent radiosensitization of colon cancer cells.

Cancer biotherapy & radiopharmaceuticals - 1 Dec 2009

Chen Xufeng, Wong Patty, Radany Eric, Wong Jeffrey Y C

Abstract excerpt

Agents that inhibit histone deacetylases (HDAC inhibitors) have been shown to enhance radiation response. The aim of this study was to evaluate the effects of low, minimally cytotoxic concentrations of the HDAC inhibitor, valproic acid (VPA), on radiation response of colorectal cancer cells. Cell lines LS174T and an isogenic pair of HCT116, which differed only for the presence of wild-type p53, were exposed to...

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Source

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Identifiers

PMID: 20025549
DOI: 10.1089/cbr.2009.0629
PMCID: PMC2920759

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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