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Selective killing of cancer cells harboring mutant RAS by concomitant inhibition of NADPH oxidase and glutathione biosynthesis.

Cell death & disease - 16 Feb 2021

Liu Muyun, Wang Dan, Luo Yongde, Hu Lianghao, Bi Yawei, Ji Juntao, Huang Haojie, Wang Guoqiang, Zhu Liang, Ma Jianjia, Kim Eunice, Luo Catherine K, Abbruzzese James L, Li Xiaokun, Yang Vincent W, Li Zhaoshen, Lu Weiqin

Abstract excerpt

Oncogenic RAS is a critical driver for the initiation and progression of several types of cancers. However, effective therapeutic strategies by targeting RAS, in particular RASG12D and RASG12V, and associated downstream pathways have been so far unsuccessful. Treatment of oncogenic RAS-ravaged cancer patients remains a currently unmet clinical need. Consistent with a major role in cancer metabolism, oncogenic RAS...

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Identifiers

PMID: 33594044
DOI: 10.1038/s41419-021-03473-6
PMCID: PMC7887267

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