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Article

Thymidylate synthase inhibition triggers apoptosis via caspases-8 and -9 in both wild-type and mutant p53 colon cancer cell lines.

European journal of cancer (Oxford, England : 1990) - 1 Jun 2003

Backus H H J, Wouters D, Ferreira C G, van Houten V M M, Brakenhoff R H, Pinedo H M, Peters G J

Abstract excerpt

Thymidylate synthase (TS) is an important target for chemotherapy and increased levels are associated with resistance to colorectal cancer chemotherapy. TS can be inhibited by 5-fluorouracil (5-FU) and antifolates, ultimately resulting in apoptosis. We aimed to clarify whether activation of caspases and Fas signalling are crucial for the onset of apoptosis after specific inhibition of TS and whether p53 plays a...

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Identifiers

PMID: 12763222
DOI: 10.1016/s0959-8049(03)00204-1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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