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Differential anti-tumour effects of MTH1 inhibitors in patient-derived 3D colorectal cancer cultures

28 Jan 2019

Abstract excerpt

Reactive oxygen species (ROS) function as second messengers in signal transduction, but high ROS levels can also cause cell death. MTH1 dephosphorylates oxidized nucleotides, thereby preventing their incorporation into DNA and protecting tumour cells from oxidative DNA damage. Inhibitors of MTH1 (TH588 and (S)-crizotinib) were shown to reduce cancer cell viability. However, the MTH1-dependency of the anti-cancer...

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PMID: 30692572
DOI: 10.1038/s41598-018-37316-w

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