Methylglyoxal Scavengers Resensitize KRAS-Mutated Colorectal Tumors to Cetuximab.

doi:10.1016/j.celrep.2020.01.012

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Article

Methylglyoxal Scavengers Resensitize KRAS-Mutated Colorectal Tumors to Cetuximab.

Cell reports - 4 Feb 2020

Bellier Justine, Nokin Marie-Julie, Caprasse Maurine, Tiamiou Assia, Blomme Arnaud, Scheijen Jean L, Koopmansch Benjamin, MacKay Gillian M, Chiavarina Barbara, Costanza Brunella, Rademaker Gilles, Durieux Florence, Agirman Ferman, Maloujahmoum Naïma, Cusumano Pino G, Lovinfosse Pierre, Leung Hing Y, Lambert Frédéric, Bours Vincent, Schalkwijk Casper G, Hustinx Roland, Peulen Olivier, Castronovo Vincent, Bellahcène Akeila

Abstract excerpt

The use of cetuximab anti-epidermal growth factor receptor (anti-EGFR) antibodies has opened the era of targeted and personalized therapy in colorectal cancer (CRC). Poor response rates have been unequivocally shown in mutant KRAS and are even observed in a majority of wild-type KRAS tumors. Therefore, patient selection based on mutational profiling remains problematic. We previously identified methylglyoxal...

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Identifiers

PMID: 32023458
DOI: 10.1016/j.celrep.2020.01.012

Genes

KRAS
EGFR

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