Article
Ataxia telangiectasia mutated-deficient B-cell chronic lymphocytic leukemia occurs in pregerminal center cells and results in defective damage response and unrepaired chromosome damage.
Blood - 1 Jan 2002
Stankovic Tatjana, Stewart Grant S, Fegan Christopher, Biggs Paul, Last James, Byrd Philip J, Keenan Russell D, Moss Paul A H, Taylor Alexander M R
Abstract excerpt
B-cell chronic lymphocytic leukemia (B-CLL) is a heterogeneous disease involving more than one molecular mechanism that leads to the transformation of CD5(+) B cells at either the pregerminal or postgerminal center stage of differentiation. It was previously demonstrated that ataxia telangiectasia mutated (ATM) gene mutations can occur in B-CLL and cause a defect in the p53 pathway. Here the role of ATM mutations...
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