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Article

A gating mechanism for Pi release governs the mRNA unwinding by eIF4AI during translation initiation.

Nucleic acids research - 2 Dec 2015

Lu Junyan, Jiang Chenxiao, Li Xiaojing, Jiang Lizhi, Li Zengxia, Schneider-Poetsch Tilman, Liu Jianwei, Yu Kunqian, Liu Jun O, Jiang Hualiang, Luo Cheng, Dang Yongjun

Abstract excerpt

Eukaryotic translation initiation factor eIF4AI, the founding member of DEAD-box helicases, undergoes ATP hydrolysis-coupled conformational changes to unwind mRNA secondary structures during translation initiation. However, the mechanism of its coupled enzymatic activities remains unclear. Here we report that a gating mechanism for Pi release controlled by the inter-domain linker of eIF4AI regulates the coupling...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 26464436
DOI: 10.1093/nar/gkv1033
PMCID: PMC4666354

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