Article
Mutational analysis of a DEAD box RNA helicase: the mammalian translation initiation factor eIF-4A.
The EMBO journal - 1 Jul 1992
Pause A, Sonenberg N
Abstract excerpt
eIF-4A is a translation initiation factor that exhibits bidirectional RNA unwinding activity in vitro in the presence of another translation initiation factor, eIF-4B and ATP. This activity is thought to be responsible for the melting of secondary structure in the 5' untranslated region of eukary...
Topics
- Adenosine Triphosphatases
- Adenosine Triphosphate
- Amino Acid Sequence
- Autoradiography
- Cross-Linking Reagents
- Electrophoresis, Polyacrylamide Gel
- Eukaryotic Initiation Factor-4A
- Eukaryotic Initiation Factors
- Hydrolysis
- Kinetics
- Molecular Sequence Data
- Mutagenesis, Site-Directed
- Mutation
- Peptide Initiation Factors
- RNA
- RNA Helicases
- RNA Nucleotidyltransferases