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Article

Mutational analysis of a DEAD box RNA helicase: the mammalian translation initiation factor eIF-4A.

The EMBO journal - 1 Jul 1992

Pause A, Sonenberg N

Abstract excerpt

eIF-4A is a translation initiation factor that exhibits bidirectional RNA unwinding activity in vitro in the presence of another translation initiation factor, eIF-4B and ATP. This activity is thought to be responsible for the melting of secondary structure in the 5' untranslated region of eukaryotic mRNAs to facilitate ribosome binding. eIF-4A is a member of a fast growing family of proteins termed the DEAD...

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Identifiers

PMID: 1378397
DOI: 10.1002/j.1460-2075.1992.tb05330.x
PMCID: PMC556740

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Mutational analysis of a DEAD box RNA helicase: the mammalian translation initiation factor eIF-4A.PMID 1378397Read ↗

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Translation initiation factor 4A from Saccharomyces cerevisiae: analysis of residues conserved in the D-E-A-D family of RNA helicases.Semantic proximity Read ↗

Investigation of the conserved glutamate immediately following the DEAD box in eukaryotic translation initiation factor 4AI.Semantic proximity Read ↗

The Q motif: a newly identified motif in DEAD box helicases may regulate ATP binding and hydrolysis.Semantic proximity Read ↗

The requirement for eukaryotic initiation factor 4A (elF4A) in translation is in direct proportion to the degree of mRNA 5' secondary structure.Semantic proximity Read ↗

Human eukaryotic initiation factor 4G directly binds the 40S ribosomal subunit to promote efficient translationSemantic proximity Read ↗

Mutational analysis of human eIF4AIII identifies regions necessary for exon junction complex formation and nonsense-mediated mRNA decay.Semantic proximity Read ↗

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Yeast eukaryotic initiation factor 4B (eIF4B) enhances complex assembly between eIF4A and eIF4G in vivo.Semantic proximity Read ↗

The structure of a human translation initiation complex reveals two independent roles for the helicase eIF4ASemantic proximity Read ↗

Crystal structure of the eIF4A-PDCD4 complex.Semantic proximity Read ↗

Phosphorylation of eucaryotic translation initiation factor 4B Ser422 is modulated by S6 kinases.Semantic proximity Read ↗

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