Functional analysis of individual binding activities of the scaffold protein eIF4G.

doi:10.1074/jbc.M602780200

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Article

Functional analysis of individual binding activities of the scaffold protein eIF4G.

The Journal of biological chemistry - 19 Jan 2007

Hinton Tracey M, Coldwell Mark J, Carpenter Gillian A, Morley Simon J, Pain Virginia M

Abstract excerpt

Eukaryotic initiation factor (eIF) 4G is an integral member of the translation initiation machinery. The molecule serves as a scaffold for several other initiation factors, including eIF4E, eIF4AI, the eIF3 complex, and poly(A)-binding protein (PABP). Previous work indicates that complexes between these proteins exhibit enhanced mRNA cap-binding and RNA helicase activities relative to the respective individual...

Topics

Animals
Binding Sites
Eukaryotic Initiation Factor-4G
HeLa Cells
Humans
Insecta
Mice
Mutation
NIH 3T3 Cells
Peptide Hydrolases
Poly(A)-Binding Proteins
Protein Binding
RNA, Small Interfering
Rabbits
Reticulocytes

Source

Open in PubMed

Identifiers

PMID: 17130132
DOI: 10.1074/jbc.M602780200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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