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Article

Functional analysis of individual binding activities of the scaffold protein eIF4G.

The Journal of biological chemistry - 19 Jan 2007

Hinton Tracey M, Coldwell Mark J, Carpenter Gillian A, Morley Simon J, Pain Virginia M

Abstract excerpt

Eukaryotic initiation factor (eIF) 4G is an integral member of the translation initiation machinery. The molecule serves as a scaffold for several other initiation factors, including eIF4E, eIF4AI, the eIF3 complex, and poly(A)-binding protein (PABP). Previous work indicates that complexes between these proteins exhibit enhanced mRNA cap-binding and RNA helicase activities relative to the respective individual...

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Identifiers

PMID: 17130132
DOI: 10.1074/jbc.M602780200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Functional analysis of individual binding activities of the scaffold protein eIF4G.PMID 17130132Read ↗

Human eukaryotic initiation factor 4G directly binds the 40S ribosomal subunit to promote efficient translationSemantic proximity Read ↗

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Eukaryotic translation initiation factor 3 (eIF3) and eIF2 can promote mRNA binding to 40S subunits independently of eIF4G in yeast.Semantic proximity Read ↗

Structural basis for the enhancement of eIF4A helicase activity by eIF4G.Semantic proximity Read ↗

The yeast eukaryotic initiation factor 4G (eIF4G) HEAT domain interacts with eIF1 and eIF5 and is involved in stringent AUG selection.Semantic proximity Read ↗

Translational activation of uncapped mRNAs by the central part of human eIF4G is 5′ end-dependentSemantic proximity Read ↗

Functional Dissection of Eukaryotic Initiation Factor 4F: the 4A Subunit and the Central Domain of the 4G Subunit Are Sufficient To Mediate Internal Entry of 43S Preinitiation ComplexesSemantic proximity Read ↗

The Translation Initiation Factor eIF-4E Binds to a Common Motif Shared by the Translation Factor eIF-4γ and the Translational Repressors 4E-Binding ProteinsSemantic proximity Read ↗

Yeast eukaryotic initiation factor 4B (eIF4B) enhances complex assembly between eIF4A and eIF4G in vivo.Semantic proximity Read ↗

Multiple roles for the C-terminal domain of eIF5 in translation initiation complex assembly and GTPase activation.Semantic proximity Read ↗

Eukaryotic Translation Initiation Factor 4F Architectural Alterations Accompany Translation Initiation Factor Redistribution in Poxvirus-Infected CellsSemantic proximity Read ↗

Structural analysis of an eIF3 subcomplex reveals conserved interactions required for a stable and proper translation pre-initiation complex assembly.Semantic proximity Read ↗

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