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Article

Genetic variants in one-carbon metabolism genes and breast cancer risk in European American and African American women.

International journal of cancer - 1 Aug 2015

Gong Zhihong, Yao Song, Zirpoli Gary, David Cheng Ting-Yuan, Roberts Michelle, Khoury Thaer, Ciupak Gregory, Davis Warren, Pawlish Karen, Jandorf Lina, Bovbjerg Dana H, Bandera Elisa V, Ambrosone Christine B

Abstract excerpt

Folate-mediated one-carbon metabolism plays critical roles in DNA synthesis, repair and DNA methylation. The impact of single nucleotide polymorphisms (SNPs) in folate-metabolizing enzymes has been investigated in risk of breast cancer among European or Asian populations, but not among women of African ancestry. We conducted a comprehensive analysis of SNPs in eleven genes involved in one-carbon metabolism and...

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Identifiers

PMID: 25598430
DOI: 10.1002/ijc.29434
PMCID: PMC4437886

Genes

MTR
MTRR
SHMT1
TYMS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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