Article
Identification of determinants for tRNA substrate recognition by Escherichia coli C/U34 2'-O-methyltransferase.
RNA biology - 1 Jan 2015
Zhou Mi, Long Tao, Fang Zhi-Peng, Zhou Xiao-Long, Liu Ru-Juan, Wang En-Duo
Abstract excerpt
Post-transcriptional modifications bring chemical diversity to tRNAs, especially at positions 34 and 37 of the anticodon stem-loop (ASL). TrmL is the prokaryotic methyltransferase that catalyzes the transfer of the methyl group from S-adenosyl-L-methionine to the wobble base of tRNA(Leu)CAA and tRNA(Leu)UAA isoacceptors. This Cm34/Um34 modification affects codon-anticodon interactions and is essential for...
Topics
- Alkenes
- Anticodon
- Base Sequence
- Binding Sites
- Biocatalysis
- Codon
- Escherichia coli Proteins
- Kinetics
- Methylation
- Methyltransferases
- Models, Molecular
- Molecular Sequence Data
- Mutation
- Nucleic Acid Conformation
- Protein Multimerization