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Article

Identification of determinants for tRNA substrate recognition by Escherichia coli C/U34 2'-O-methyltransferase.

RNA biology - 1 Jan 2015

Zhou Mi, Long Tao, Fang Zhi-Peng, Zhou Xiao-Long, Liu Ru-Juan, Wang En-Duo

Abstract excerpt

Post-transcriptional modifications bring chemical diversity to tRNAs, especially at positions 34 and 37 of the anticodon stem-loop (ASL). TrmL is the prokaryotic methyltransferase that catalyzes the transfer of the methyl group from S-adenosyl-L-methionine to the wobble base of tRNA(Leu)CAA and tRNA(Leu)UAA isoacceptors. This Cm34/Um34 modification affects codon-anticodon interactions and is essential for...

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Identifiers

PMID: 26106808
DOI: 10.1080/15476286.2015.1050576
PMCID: PMC4615657

Genes

ASL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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