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Article

The tRNA recognition mechanism of the minimalist SPOUT methyltransferase, TrmL.

Nucleic acids research - 1 Sept 2013

Liu Ru-Juan, Zhou Mi, Fang Zhi-Peng, Wang Meng, Zhou Xiao-Long, Wang En-Duo

Abstract excerpt

Unlike other transfer RNAs (tRNA)-modifying enzymes from the SPOUT methyltransferase superfamily, the tRNA (Um34/Cm34) methyltransferase TrmL lacks the usual extension domain for tRNA binding and consists only of a SPOUT domain. Both the catalytic and tRNA recognition mechanisms of this enzyme remain elusive. By using tRNAs purified from an Escherichia coli strain with the TrmL gene deleted, we found that TrmL...

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Identifiers

PMID: 23804755
DOI: 10.1093/nar/gkt568
PMCID: PMC3763551

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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